Evolution of MRT

MRT has gone by many names since its discovery in the 1980’s, you will find many of those names in these studies
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Studies

Effect of Physiologic Insulin Resensitization Therapy in Patients with Diabetes

1 A1C - Blood Pressure - Retrospective Study - 67 person - Mercer University School of Medicine - 2022-min

Effect of Physiologic Insulin Resensitization on Stages of 2 Chronic Kidney Disease

2 Kidney Disease - 17 people - IJMS -2024-min

Effectiveness and safety of pulsatile intravenous insulin therapy for the improvement of respiratory quotient in Chinese patients with diabetes mellitus

3 Chinese study - Respiratory Quotient - 107 person - 2019-min

Efficacy Evaluation Study for Microburst Insulin Infusion: A Novel Model of Care

4 Retrospective study - 80 patients - IRB - Frontiers in Public Health - 2021-min

Case Series: Reversal of Diabetic Neuropathy Utilizing Physiologic Insulin Resensitization

5 Reduced Hospital and ER Visits - Retrospective Study - 1524 patients - Journal of DIabetes, Metabolic Disorders & Control - 2017-min

Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus

6 IIIT - Research - Type 1 Diabetes - LANCET - Aoki -1993-min

Reversal of diabetic retinopathy in two patients following the use of physiologic insulin Resensitization

6.1 Retinopathy - Journal of Diabetes - 2 patients-min

Pulsatile Insulin Treatment as a Treatment Option for Patients with Type 2 Diabetes and Stage 3 Kidney Failure

6.2 Kidney Disease - Review - Diabetes Journal-min

Improved Kidney Function Following Physiologic Insulin Resensitization Treatment Modality

6.3 Kidney Function - Review - 3 people - Lakey-min

Improved HOMA-IR Insulin Sensitivity and Glycemic Control Utilizing Physiologic Insulin Resensitization

6.4 HOMA-IR - Fortune Journals - 4 people-min

Case Series: Reversal of Diabetic Neuropathy Utilizing Physiologic Insulin Resensitization

6.5 Neuropathy Reversal - Study - 2 people - International Journal of Diabetes & Metabolic Disorders - Lakey-min

Pulsatile intravenous insulin therapy: The best practice to reverse diabetes complications?

6.6 Diabetes Complications - ELSEVIER - Research - PIVIT - FIT - 2009-min

Dynamic diabetes solutions physiologic insulin resensitization

7.1 Detailed Review - Medical and Clinical Research - 2021 - Lakey-min

Effects of Periodic Intensive Insulin Therapy: An Updated Review

7.2 Research - ELSEVIER - 2019 - Lakey-min

Dynamic Diabetes Solutions: Physiologic Insulin Resensitization

7.3 Review - International Journal of Diabetes & Metabolic Syndrome - Lakey-min

Chronic Intermittent Intravenous Insulin Therapy (CIIIT) - CAM 20143

8 Medical policy - CIIIT - 2001-min

Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology

9 Insulin Resistance - Reason for MRT - Lakey - International Journal of Molecular Sciences - 2022-min

Insulin Therapy for Type 2 Diabetes: Rescue, Augmentation, and Replacement of Beta-Cell Function

9.1 Beta cell function - Research - Reason for MRT - Mayfield - 2004-min

Pulsatility of insulin release – a clinically important phenomenon

9.2 Abstract - Pulsatile Nature of Beta Cells - Upsala Journal of Medical Sciences - 2009-min

Measurement of Pulsatile Insulin Secretion: Rationale and Methodology

9.3 Rationale and Methodology - Pulsatile Nature of Beta Cells - PubMed - 2021-min

Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology

9.4 Type 2 Diabetes - Opinion - International Journal of Molecular Sciences - 2022-min

Pulsatile I.V. Insulin Therapy for Severely Out of Control Diabetes

9.5 PIVIT for Out of Control Diabetes - Abstract of Study - Journal of Infusion Nursing - 1995-min

Physiologic hormone administration improves HbA1C in Native Americans with type 2 diabetes: A retrospective study and review of insulin secretion and action

9.6 MRT in Native Americans - Review of Data - 2023-min

Frequently Asked Questions

Your quick answers here, saving you time and hassle
Will MRT reverse diabetes?
Although, anecdotally, there have been many documented cases, the data supports that when combined with already existing diabetes strategies, MRT can significantly slow or stop the progression of kidney disease, neuropathy, retinopathy, and reduce A1C and overall blood sugar levels and spikes.
Under proper training this therapy is extremely safe. Anytime insulin is infused there is risk of a crash. Through proper training and protocols this is extremely rare and in almost all cases patients recover with simple oral glucose.
There are no long term negative side effects recorded from this therapy. Occasional short term symptoms can be similar to those experienced with dietary changes intended to improve diabetes. Most experience slow and gradual improvement of symptoms associated with diabetes.
Treatment protocols are specific to the severity of the conditions and lifestyle of the patient. For most moderate to severe cases, Phase 1 treatments will start 2 times a week for 2-8 weeks, then progress to Phase 2 at 1 time a week until they achieve desired goals or max improvement, commonly 2-6 months. Following this phase they enter maintenance which can vary between 1 visit every 2-12 weeks, depending on lifestyle.
Treatment times vary based on severity and patients’ response to treatment. Typically we suggest planning on 3 hours for moderate to severe patients and 2-3 hours for mild and maintenance visits. In some cases, providers may recommend doing more frequent visits for less time per visit.

This will depend on how many chairs you decide to set up. The minimum we recommend is 4 chairs, which would require about a 8′ by 12′ space to operate comfortably. We recommend open space so patients can visit and hear each others success stories as they are in treatment.

Each office will determine it’s own best flow. Our recommendation is for an existing medical office adding 4 or 6 chairs. One full time RN and MA (with phlebotomy certification) are enough to operate the chairs under supervision of an existing MD or NP (if state allows).
MRT can be a stand alone therapy, but can also draw patients to the clinics with many other needs. You may already offer other services or may want to add services that can bless and improve their lives and help grow your revenue opportunities. Once you implement MRT successfully feel free to ask about other services and revenue streams that you could add.
We advise clinics to add MRT as a cash based service as it does not have it’s own designated HCPCS or CPT codes. Although many choose to bill MRT as an off-label use of insulin, billing and basing medical necessity on hydration and IV therapy, we advise against this practice as it comes with risk of audit and potential claw backs. Part of your royalty fee goes toward the large scale studies and lobbying needed to be recognized with its own CPT codes. We are working aggressively in this space but will take some time. May be accelerated with Robert Kennedy’s support as the Secretary of Health 🙂 Go MAHA!
Yes we have developed protocols for this purpose, although results will likely not be as significant or delayed. We have found that less frequent visits can still achieve results when necessary.

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